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Previously begun on another site under another pen-name - this is my original work.Epidemiological data demonstrate that while women report lower rates of drug use than men, the number of current drug users and abusers who are women continues to increase.

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Sunni insurgent groups are likely to raise their own game, in order to challenge the Shi’ite dominated government and demonstrate its inability to ensure security — an exercise that will suit the agenda of their own backers. Unfortunately, instead, that withdrawal coincides with a sharp escalation in the Saudi-Iranian cold war, and that will spell trouble for Iraq. ABSTRACT: Childhood and adolescence are sensitive periods of development, marked by high brain maturation and plasticity.Exposure to early life stress, such as social isolation, is able to prompt changes in sensitive brain circuitries, essentially in the mesolimbic dopaminergic system and increase the risk for addictive behaviors later in life.However, the downstream mechanisms that result from interactions between estrogen and the effects of drugs of abuse on the DA system are just beginning to be explored.Here we review the basic neurocircuitry which underlies reward and addiction; highlighting the neuroadaptive changes that occur in the mesolimbic dopamine reward and anti-reward/stress pathways.

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